Wireless telephone use, caller ID, and call blocking pose challenges to telephone-based data collection for epidemiological studies; smartphones, tablets, and increased access to the internet have removed both time and place demands of home-based communications. Telephone-based data collection in Iowa for the NBDPS has indicated a steady decline in participation rates. This case-control study will evaluate a web-based approach for molecular environmental epidemiological studies of adverse pregnancy outcomes. 240 infants with selected birth defects and 240 infants without defects will be selected and equally assigned to a web-based or a telephone-based group. They will be administered a questionnaire for maternal environmental exposures; mothers in the web-based group will electronically sign a consent form to use residual newborn bloodspots for biomonitoring; for the telephone-based group, the U.S. Postal Service will be used for hand-signed informed consents. Participation rates, sample representativeness, exposure reporting, and costs between the web-based and telephone-based groups will be compared. Investigators hypothesize that improved participation rates will be seen in the web-based group, which will permit increased generalization of study results and increased statistical power for studies.